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Journal of Oncology
Volume 2018, Article ID 3970169, 7 pages
https://doi.org/10.1155/2018/3970169
Review Article

Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature

13rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
2Department of Haematology and Stem Cell Transplantation, St. István and St. László Hospital, Budapest, Hungary
3Department of Neurology, Semmelweis University, Budapest, Hungary
4Heart and Vascular Center, Division of Diagnostic Imaging, Semmelweis University, Budapest, Hungary
51st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary

Correspondence should be addressed to Gergely Varga; moc.liamg@regagrav

Received 27 November 2017; Accepted 18 March 2018; Published 23 April 2018

Academic Editor: Minesh P. Mehta

Copyright © 2018 Gergely Varga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. V. Rajkumar, M. A. Dimopoulos, and A. Palumbo, “International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma,” The Lancet Oncology, vol. 15, no. 12, pp. e538–e548, 2014. View at Publisher · View at Google Scholar
  2. S. K. Kumar, A. Dispenzieri, M. Q. Lacy et al., “Continued improvement in survival in multiple myeloma: Changes in early mortality and outcomes in older patients,” Leukemia, vol. 28, no. 5, pp. 1122–1128, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Jurczyszyn, N. Grzasko, A. Gozzetti et al., “Central nervous system involvement by multiple myeloma: A multi-institutional retrospective study of 172 patients in daily clinical practice,” American Journal of Hematology, vol. 91, no. 6, pp. 575–580, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Dispenzieri and R. A. Kyle, “Neurological aspects of multiple myeloma and related disorders,” Best Practice & Research Clinical Haematology, vol. 18, no. 4, pp. 673–688, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Paludo, U. Painuly, and S. Kumar S, “Myelomatous involvement of the central nervous system , Clinical Lymphoma,” Myeloma & Leukemia, vol. 16, no. 11, pp. 644–654, 2016. View at Publisher · View at Google Scholar
  6. K. O. Schluterman, A. B.-T. Fassas, R. L. Van Hemert, and S. I. Harik, “Multiple myeloma invasion of the central nervous system,” JAMA Neurology, vol. 61, no. 9, pp. 1423–1429, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. I. Chen, E. Masih-Khan, H. Jiang et al., “Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents,” British Journal of Haematology, vol. 162, no. 4, pp. 483–488, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. A. O. Abdallah, S. Atrash, Z. Shahid, and etal., “Patterns of central nervous system involvement in relapsed and refractory multiple myeloma,” Clinical Lymphoma, Myeloma & Leukemia, vol. 14, no. 3, pp. 211–214, 2014. View at Google Scholar
  9. N. Majd, A. Demopoulos, and A. Chari, “Central nervous system involvement in multiple myeloma patients in the era of novel therapies, neurology,” Neurology, vol. 80, no. 7, 2013. View at Google Scholar
  10. A. Gozzetti, A. Cerase, F. Lotti et al., “Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients,” Cancer, vol. 118, no. 6, pp. 1574–1584, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. L. Dias, F. Higashi, A. L. Peres, P. Cury, E. d. Crusoé, and V. T. Hungria, “Multiple myeloma and central nervous system involvement: experience of a Brazilian center,” Hematology, Transfusion and Cell Therapy, vol. 40, no. 1, pp. 30–36, 2018. View at Publisher · View at Google Scholar
  12. H. Chang, S. Sloan, D. Li, and A. K. Stewart, “Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions,” British Journal of Haematology, vol. 127, no. 3, pp. 280–284, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. B.-T. Fassas, F. Muwalla, T. Berryman et al., “Myeloma of the central nervous system: association with high-risk chromosomal abnormalities, plasmablastic morphology and extramedullary manifestations,” British Journal of Haematology, vol. 117, no. 1, pp. 103–108, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Istenes, Zs. Nagy, and J. Demeter, “Chemotherapy-induced peripheral neuropathy: characteristics, diagnosis and treatment,” Hungarian Oncology, vol. 60, pp. 165–175, 2016. View at Google Scholar
  15. R. A. Rison and S. R. Beydoun, “Paraproteinemic neuropathy: A practical review,” BMC Neurology, vol. 16, no. 1, article no. 13, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Badros, Z. Singh, B. Dhakal et al., “Marizomib for central nervous system-multiple myeloma,” British Journal of Haematology, vol. 177, no. 2, pp. 221–225, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Mussetti, S. Dalto, and V. Montefusco, “Effective treatment of pomalidomide in central nervous system myelomatosis,” Leukemia & Lymphoma, vol. 54, no. 4, pp. 864–866, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Leleu, L. Karlin, M. Macro et al., “Pomalidomide plus low-dose dexamethasone in multiple myeloma with deletion 17p and/or translocation (4;14): IFM 2010-02 trial results,” Blood, vol. 125, no. 9, pp. 1411–1417, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Nieuwenhuizen and D. H. Biesma, “Central nervous system myelomatosis: review of the literature,” European Journal of Haematology, vol. 80, no. 1, pp. 1–9, 2008. View at Publisher · View at Google Scholar · View at Scopus