| Amsterdam criteria I |
| (1) At least three relatives with CRC |
| (2) One of which is a first-degree relative of the other two |
| (3) Colorectal cancer affecting at least two successive generations |
| (4) At least one patient with colorectal cancer diagnosed <50 years |
| (5) Familial adenomatous polyposis should be excluded |
| (6) Tumors should be verified by pathologic examination |
| Amsterdam criteria II |
| (1) There should be at least three relatives with an HNPCC-associated cancer (CRC, cancer of the |
| endometrium, small bowel, ureter, or renal pelvis) |
| (2) One patient must be a first-degree relative of the other two |
| (3) Colorectal cancer affecting at least two successive generations |
| (4) As least one patient should be diagnosed <50 year |
| (5) Familial adenomatous polyposis should be excluded |
| (6) Tumors should be verified by pathologic examination |
| Revised Bethesda criteria |
| (1) CRC diagnosed in one patient <50 years |
| (2) Presence of synchronous or metachronous, colorectal or other HNPCC-associated tumors |
| (3) Pathologic features of a microsatellite instability-high cancer diagnosed in a patient <60 years |
| (4) CRC diagnosed in a patient with at least one first-degree relatives with an HNPCC-related |
| tumor with one of the cancer diagnosed <50 years (including adenoma <40 years) |
| (5) CRC diagnosed in a patient with at least two first-or second-degree relatives with HNPCC- |
| related tumors |
