Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients

Table 3

Uni- and multivariate correlates of fatal pulmonary hemorrhage in patients with tumor cavitation.

Variable	Patients; (N=60)	FPH; (N=13)	Univariate P-value	Multivariate; P-value
Median TS, n (%)
<5.1 cm	27 (45.0)	6 (22.2)	0.68	-
≥5.1 cm	33 (54.0)	7 (21.2)
Median TV, n (%)
≤58.9 cm^3	26 (43.3)	5 (19.2)	0.57	-
>58.9 cm^3	34 (56.7)	8 (23.4)
Median CS, n (%)
< 2.6 cm	28 (46.7)	6 (21.4)	0.86	-
≥ 2.6 cm	32 (53.3)	7 (21.9)
Median CV, n (%)
< 22.3 cm^3	27 (45.0)	5 (18.5)	0.23	-
≥ 22.3 cm^3	33 (55.0)	8 (242
Median RCS, n (%)
< 0.46	31 (51.7)	5 (16.1)	0.09	-
≥ 0.46	29 (48.3)	8 (27.6)
Ito’s RCS group, n (%)
Minimum (≤0.25)	10 (16.7)	0 (0)	0.006	0.008
Minor (≥0.25 but <0.50)	21 (35.0)	4 (19.0)
Major (≥0.5)	29 (48.3)	9 (31.0)
RCV group, n (%)
≤0.14	36 (55.0)	4 (11.1)	<0.001	<0.001
>0.14	24 (45.0)	9 (37.5)
Hemoptysis, n (%)
Absent	22 (36.7)	3 (13.6)	0.007	0.009
Present	38 (63.3)	10 (26.3)

Median values were used, as receiver operating characteristic analysis did not reveal significant cut-off.
FPH: fatal pulmonary hemorrhage; TS: tumor size; TV: tumor volume; CS: cavitation size; CV: cavitation volume; RCS: relative cavitation size (largest tumor diameter/largest cavitation diameter); RCV: relative cavitation volume (cavitation volume/tumor volume).