MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer

Figure 5

MiR-30a regulates drug susceptibility through EMT signaling, P-gp signaling, and other relevant target genes. EMT not only regulates cell invasion and metastasis but also participates in drug resistance. In cisplatin-resistant gastric cancer cells, the expressions of Snail and Vimentin are higher, but with lower expression of miR-30a and E-cadherin expression. However, the loss of epithelial markers and mesenchymal markers is correlated with MDR development. Besides, miR-30a overexpression increases paclitaxel sensitivity by inhibiting BCL-2 expression in nonsmall cell lung cancer. In addition, CAGE expression promotes miR-30a expression, which inhibits p53 expression, increasing drug resistance by forming miR-30a-CAGE-p53 feedback loop.