Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma

Table 2

The metabolic pathways of Human species related to the 12 differentially expressed genes in OSCC.

Human metabolic pathways	Genes
Metabolism of xenobiotics by cytochrome P450	CYP2E1, CYP4B1 and CYP4F12
Chemical carcinogenesis	CYP2E1 and CYP4B1
Drug metabolism by cytochrome P450	CYP2E1, MAOB, CYP4B1 and CYP4F12
Serotonergic synapse	ALOX12, CYP2J2, CYP4X1 and MAOB
Arachidonic acid metabolism	ALOX12, CYP2E1, CYP2J2, CYP2U1, CYP4F12 and PTGIS
Inflammatory mediator regulation of TRP channels	ALOX12 and CYP2J2
PPAR signaling pathway	CYP27A1
Steroid biosynthesis	CYP2R1 and CYP27B1
Steroid hormone biosynthesis	CYP2E1
Primary bile acid biosynthesis	CYP27A1
Linoleic acid metabolism	CYP2E1 and CYP2J2
Amino acids metabolism	MAOB
Ovarian steroidogenesis	CYP2J2
Tuberculosis	CYP27B1
Nonalcoholic fatty liver disease (NAFLD)	CYP2E1
Dopaminergic synapse	MAOB
Amphetamine, cocaine, and alcohol addiction	MAOB

TRP: Transient Receptor Potential; PPAR: Peroxisome Proliferator Activated Receptors. The amino acids include glycine, serine, threonine, tyrosine, tryptophan, histidine, arginine, proline, and phenylalanine.