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Journal of Oncology
Volume 2018, Article ID 6384253, 7 pages
https://doi.org/10.1155/2018/6384253
Research Article

The Efficacy of Conventionally Fractionated Radiation in the Management of Osseous Metastases from Metastatic Renal Cell Carcinoma

Department of Radiation Oncology, University of Kansas Cancer Center, Kansas University Medical Center, Kansas City, KS, USA

Correspondence should be addressed to Rohit Gunan Ganju; ude.cmuk@ujnagr

Received 28 September 2017; Revised 18 November 2017; Accepted 7 December 2017; Published 9 January 2018

Academic Editor: Akira Hara

Copyright © 2018 Rohit Gunan Ganju et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. There is little data regarding the effectiveness of palliative radiation with conventional fractionation for metastatic renal cell carcinoma (RCC), which has been described as radioresistant. We conducted a retrospective analysis of patients with metastatic bony disease from RCC treated with radiation therapy at our institution. Methods. Forty patients with histologically confirmed RCC with a total of 53 treatment courses were included. Pain response after radiotherapy was recorded and freedom from progression was generated using posttreatment radiographs. Patient data was analyzed to assess influence on local control. Results. Patients had a median age of 63. Median follow-up was 9.3 months. The most common radiation dose was 30 Gy in 10 fractions. Pain control after radiotherapy was achieved in 73.6% of patients. Increasing age was associated with nonresponse at the initial pain assessment post-RT . In lesions with initial pain response, nonclear cell histology was associated with increased pain recurrence and a shorter duration to pain recurrence . Radiographic control at 1 year was 62%. Conclusions. Pain response and control rates for osseous metastatic disease in RCC are comparable to other histologies when treated with conventional fractionation. These appear to be inferior to reported control rates from stereotactic treatments.