Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study

Table 2

Association between haplotypes of PSORS1C1 and STARD3 and NM23 expression.

Haplotypes	NM23				Ad OR^★	P–value	Ad	P–value	Ad	P–value
	—	1+	2+	3+	(95% CI)		(95% CI)		(95% CI)
PSORS1C1
TGCACA	40	273	61	63	Ref.		Ref.		Ref.
CAGGTG	37	171	19	20	0.44; (0.3 0–0.65)	2.70 × 10^-5	0.71; (0.42–1.22)	0.219	0.87; (0.46–1.63)	0.653
CAGACA	6	64	9	5	0.56; (0.32–0.99)	0.048	0.99; (0.65–1.51)	0.967	1.66; (0.95–2.90)	0.073
Others	3	36	3	6	0.60; (0.3 0–1.18)	0.135	0.97; (0.74–1.27)	0.805	2.04; (0.99–4.20)	0.054
All others	46	271	31	31	0.48; (0.35–0.68)	2.05 × 10^-5	0.93; (0.73–1.18)	0.561	0.74; (0.50–1.10)	0.136
STARD3
GG	46	329	58	69	Ref.		Ref.
Others	40	209	34	25	0.65; (0.47–0.91)	0.012	0.97; (0.76–1.24)	0.814	1.18; (0.74–1.88)	0.498

Note. ^★OR, ^†HR and P–value are adjusted for age, gender, race, smoking status, drinking status, BMI, BCLC stage, Child–Pugh stage, preoperative serum AFP level, TACE status before hepatectomy, pathological grade, cirrhosis, intrahepatic metastasis, PVTT, regional invasion, radical resection, and use of antiviral therapies. Others include CGCACA and CGGGCA. The group of all others is merged CAGGTG, CAGACA, CGCACA, and CGGGCA. Others include CA, GA, CG, and the total number of patients harbour GA and CG is 6.
Abbreviations. OR: odds ratio; HR: hazard ratio; 95% CI: 95% confidence intervals; Ad: adjusted.