Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment In Vitro

Table 2

Patient characteristics of 498 pediatric neuroblastomas adopted from the MAQC-III/SEQC study. Data presented as number (%).

	MAQC-III/SEQC^a
	n=498
Age
<18 months	300 (60.2)
≥18 months	198 (39.8)
Gender
Male	287 (57.6)
Female	211 (42.4)
INSS stage
4S	53 (10.6)
1	121 (24.3)
2	78 (15.7)
3	63 (12.7)
4	183 (36.8)
Risk group
High risk	176 (35.3)
MYCN status
Amplification	92 (18.5)
Non-amplification	401 (80.5)
Unknown	5 (1.0)
HMGB1 mRNA expression^b
Upregulation	55 (11.0)
Downregulation	50 (10.0)
No alteration	393 (79.0)

the NCBI GEO database [28], accession GSE49711 dataset [29].
^bHMGB1 mRNA expression in NB tumors, where upregulation and downregulation were defined by the z-score >1.25 and <-1.25, respectively.
INSS, International Neuroblastoma Staging System.