Review Article
Immunomodulatory Effects of Drugs for Effective Cancer Immunotherapy
Table 1
Effects on cytokine productions by commonly used drugs.
| | | IL-1 | IL-6 | IL-8 | TNF-α | IFN-γ | IL-2 | IL-4 | IL-12 | IL-18 | TNF-β | IL-3 | IL-5 | IL-10 | IL-13 |
| | H2 receptor antagonist | | | | | | | | | | | | | | | | NSAIDs | | | | | | | | | | | | | | | | Prostaglandin | | | | | | | | | | | | | | | | Norfloxacin | | ↓ | | ↓ | | | | | | | | | ↑ | | | Linezolid | ↓ | ↓ | ↓ | ↓ | ↓ | | | | | | | | ↑ | | | Macrolide | ↓ | | ↓or↑ | ↑ | ↓ | ↓ | ↓or↑ | | ↓or↑ | | | ↓or↑ | | ↓or↑ | | Antifungal drugs | | ↑ | | | ↑ | ↑ | | | | ↓ | | | ↓ | | | β2 adrenalin agonist | | | | | | | | | | | | | | | | D2 receptor agonist | | | | | | | | | | | | | | | | ACE inhibitor | | | | ↓ | | | | | | | | | | | | ARB | | | | ↓ | ↓ | | | | | | | | | | | Ca channel blocker | ↓or↑ | ↓or↑ | | ↓ | ↓ | ↑ | | | | | | | | | | Digoxin | | | | | | | | | | | | | | | | DPP4 inhibitor | | | | | | | | | | | | | | | | GLP-1 receptor agonist | | | | | ↓ | | ↓ | | | | | | | | | Biguanide | | | | | | | | | | | | | | | | Statin | | | | ↓ | | | | | | | | | | |
|
|
