Quantitative Metastatic Lymph Node Regions on Magnetic Resonance Imaging Are Superior to AJCC N Classification for the Prognosis of Nasopharyngeal Carcinoma
Table 3
Univariable and multivariable analyses for distant metastasis-free survival.
Variable
Univariable
Multivariable
No. (%)
Hazard Ratio (95% CI)
P
Hazard Ratio (95% CI)
P
Age
0.118
≤ 49
177 (50.0)
1 (reference)
> 49
177 (50.0)
1.02 (0.99-1.04)
Gender
0.819
Male
266 (75.1)
1 (reference)
Female
88 (24.9)
1.07 (0.58-1.98)
T classification (AJCC )
0.019∗
T1-2
183 (51.7)
1 (reference)
T3-4
171 (48.3)
2.73 (1.34-5.60)
N classification (AJCC )
<0.001∗
N0-1
177 (50.0)
1 (reference)
N2
87 (24.6)
2.76 (1.46-5.22)
0.009
N3
90 (25.4)
4.93 (2.78-8.75)
<0.001
Laterality
0.008
Nil/Unilateral
199 (56.2)
1 (reference)
Bilateral
155 (43.8)
2.11(1.22-3.66)
Lower neck involvement
0.001
No
275 (77.7)
1 (reference)
Yes
79 (22.3)
2.49 (1.45-4.36)
SCF involvement
0.001
No
319 (90.1)
1 (reference)
Yes
35 (9.9)
3.72 (2.02-6.86)
Necrosis
No
211 (59.6)
1 (reference)
Yes
143 (40.4)
3.55 (2.00-6.32)
ECE
0.008
0.080
No
177 (50.0)
1 (reference)
1 (reference)
Yes
177 (50.0)
3.73 (1.96-7.09)
1.98 (0.92-4.26)
MLD
<0.001
<0.001
≤ 6cm
323 (91.2)
1 (reference)
1 (reference)
> 6cm
31 (8.8)
6.20 (3.44-11.14)
4.11(2.23-7.56)
LRN
<0.001∗
<0.001∗
0~1
78 (22.0)
1 (reference)
1 (reference)
2~6
180 (50.8)
5.34 (1.58-17.95)
0.034
4.59 (1.36-15.49)
0.039
≥7
96 (27.1)
13.78 (4.13-45.93)
<0.001
9.78 (2.88-33.25)
0.002
Cumulative cisplatin dose
0.040
0.028
< 300mg/m2
301 (84.8)
1 (reference)
1 (reference)
≥ 300mg/m2
53 (14.9)
0.34 (0.12-0.95)
0.32 (0.12-0.88)
Abbreviations: AJCC: American Joint Committee on Cancer; MLD: maximal lymph node diameter; SCF: supraclavicular fossa; ECE: extracapsular extension; LRN: number of involved lymph node regions. ∗Overall P value for multiple categorical variables.
