EGFR^vIII: An Oncogene with Ambiguous Role

Figure 2

Currently proposed models of EGFR^vIII dimerization. (a) Covalently or noncovalently linked EGFR^vIII homodimers. In both cases, phosphorylation of tyrosine residues of both monomers can be observed. (b) Heterodimerization of EGFR^vIII with ligand-activated (e.g., EGF-activated) EGFR^WT. Only EGFR^vIII phosphorylation is observed in such a case. (c) EGFR^vIII dimers with monomers of other inactive receptors. Example of FAK-mediated EGFR^vIII dimerization with HGFR, resulting in phosphorylation of HGFR tyrosine residues.

(a)

(b)

(c)