EGFR^vIII: An Oncogene with Ambiguous Role

Table 2

Issues addressed in the article (except therapies in Table 1).

EGFR^vIII issue/process	Mechanism/way to address	Selected references
EGFR^vIII presence in tumors/cancers	GB in about 40%, rarely in HNCSCC, lung prostate, colorectal cancer, breast cancer	[27, 33–41, 43]
EGFR^vIII mechanism of mutation	Deletion of EGFR exons 2–7	[26–29, 43]
EGFR^vIII mechanism of action	Several models: (1) Heterodimerization with EGFR^WT; (2) Homodimerization; (3) EGFR^vIII and MET cooperation, FAK involved; (4) OSMR mechanism; Resistant to degradation important for all models	[16, 17, 121–126, 142, 143]
EGFR^vIII biological role	Extreme opinions: from lack of important role at advanced cancer (tumor) stages, to role in self-renewal, survival, and proliferation of cancer stem cells	[33, 147, 150, 152–158, 164, 165]
EGFR^vIII cell culture models	3D primary cell cancer cell models, DK-MG model, genetically modified cancer cell lines	[21, 150, 153, 167, 242–244, 246–248]