Research Article

Chemoresistance in the Human Triple-Negative Breast Cancer Cell Line MDA-MB-231 Induced by Doxorubicin Gradient Is Associated with Epigenetic Alterations in Histone Deacetylase

Figure 1

Tracking DOX concentration-gradient induced resistant cells on the chip. Schematic figure (a) and real image (b) of a CDRA chip. (c) Tracking the number of live cells in each chamber of a CDRA chip for 11 days. (d) Average number of polarized cells in the three different DOX concentration regions (red (high), green (mid), and blue (low)) over 11 days.

(a)
(b)
(c)
(d)