Chemoresistance in the Human Triple-Negative Breast Cancer Cell Line MDA-MB-231 Induced by Doxorubicin Gradient Is Associated with Epigenetic Alterations in Histone Deacetylase

Figure 3

Tumor initiation ability of WT and DOXR cells. (a) Images of WT and DOXR cell sphere acquired at day 8. Black bar = 100 μm. (b) Number of WT and DOXR cell spheres counts at day 8. p < 0.01, two-tailed Student’s t-test. (c) Tumorigenicity of WT and DOXR cells in the orthotopic xenograft after 3 weeks. (d) Tumor volume of DOXR cell-injected xenograft (N = 8).

(a)

(b)

(c)

(d)