Research Article
The Choice of Local Treatment Modalities for Patients with Brain Metastases from Digestive Cancers
Table 5
Univariate and multivariate analyses for brain metastasis.
| | Univariable | Multivariable | HR (95% CI) | value | HR (95% CI) | value |
| Age, years (≥65 vs <65) | 1.04 (0.74–1.46) | 0.81 | — | | Gender (male vs female) | 1.40 (0.98–2.01) | 0.08 | — | | ECOG performance score (2–4 vs 0/1) | 2.68 (1.92–3.76) | <0.01 | 2.31 (1.61–3.33) | <0.01 | Primary disease site | | | | | Esophagus vs liver | 0.62 (0.34–1.12) | 0.11 | 0.61 (0.33–1.11) | 0.11 | Gastric vs liver | 1.27 (0.74–2.16) | 0.39 | 0.90 (0.52–1.56) | 0.70 | Colorectum vs liver | 1.20 (0.76–1.88) | 0.43 | 0.68 (0.42–1.10) | 0.11 | Primary histology | | | | | Hepatocellular carcinoma vs others | 3.57 (1.07–11.87) | 0.04 | | | Squamous cell carcinoma vs others | 2.18 (0.63–7.47) | 0.22 | | | Adenocarcinoma vs others | 3.45 (1.10–10.85) | 0.03 | | | Radical surgery for primary tumor (yes vs no) | 0.66 (0.48–0.92) | 0.01 | 1.15 (0.73–1.82) | 0.55 | Presence of extracranial metastasis (yes vs no) | 1.77 (1.20–2.62) | <0.01 | 1.56 (1.03–2.36) | 0.04 | Synchronous or subsequent brain metastasis | 0.71 (0.50–1.00) | 0.05 | 0.79 (0.50–1.25) | 0.32 | Number of brain metastasis | | | | | 1 vs ≥4 | 0.42 (0.30–0.60) | <0.01 | 0.54 (0.37–0.79) | <0.01 | 2∼3 vs ≥4 | 0.57 (0.37–0.88) | 0.01 | 0.70 (0.45–1.11) | 0.13 | Local treatment for brain metastasis (yes vs no) | 0.21 (0.15–0.29) | <0.01 | 0.26 (0.18–0.38) | <0.01 |
|
|
HR, hazard ratio; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group.
|