Mutated WT1, FLT3-ITD, and NUP98-NSD1 Fusion in Various Combinations Define a Poor Prognostic Group in Pediatric Acute Myeloid Leukemia

Figure 5

Prognostic significance of mutational burden of FLT3-ITD. (a) FLT3-ITD with an allelic ratio ≥0.4 as a single factor predicted poor outcomes. (b) High mutational burden of FLT3-ITD was another predictor of poor prognosis when it occurred with WT1 and/or NUP98-NSD1. Patients with an unknown FLT3-ITD AR were excluded from this analysis. NUP98-NSD1, Nucleoporin-Nuclear Receptor Binding SET Domain Protein 1 fusion gene; FLT3-ITD, fms related tyrosine kinase 3-internal tandem duplication; pEFS, probability of event-free survival; pOS, probability of overall survival; CIR, cumulative incidence of relapse; AR, allelic ratio; SE, standard error; n, number. No response to treatment was considered as the occurrence of an event at time zero. Three patients with NUP98-NSD1 are included in this group.