Interfering Expression of Chimeric Transcript SEPT7P2-PSPH Promotes Cell Proliferation in Patients with Nasopharyngeal Carcinoma

Figure 1

RNA sequencing was used to discover SEPT7P2-PSPH fusion gene in NPC. (a) Detection of SEPT7P2-PSPH fusion gene via RNA sequencing. The reads are aligned across the junction of the predicted fusion transcripts. (b) Circos plot of SEPT7P2-PSPH fusion gene revealed the fusion existing in chromosome 7. (c) The fusion breakpoint was verified using Sanger sequencing. (d) A schematic illustration of the amplified regions of fusion gene with exons 1-2 of SEPT7P2 and exons 3-4 of PSPH. (e) The sequences between exons 1 and 2 of SEPT7P2 and the sequences between exons 3 and 4 of PSPH were all amplified by RT–PCR.

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