Review Article

Management of Advanced and Metastatic Prostate Cancer: A Need for a Sub-Saharan Guideline

Table 3

The available treatment modalities, the medications used, and the outcomes of treatment in some studies.

StudyAvailable treatment modalityAvailable hormonotherapy drugsOutcome

Diallo et al. [8]Surgical ADT (76.3%), medical ADT (22.4%)Cyproterone acetate8% castrate resistant
Botcho et al. [9]Surgical ADT (38.6%), medical ADT, both (18.9%)Cyproterone acetate, flutamide, LHRH analogue, chemotherapy
Tengue et al. [12]Surgical ADT (34.5%), medical ADT (12.5%), both (46.1%)Cyproterone acetate, flutamide15.1% mortality
Kirakoya et al. [10]Surgical ADT (24.3%), medical ADT (62.2%), both (13.4%)Cyproterone acetate, LHRH analogue10.9% mortality
Kaboré et al. [14]Surgical ADT (43.3%), medical ADT (19%), both (9.5%)Cyproterone acetate, LHRH analogue
Wasike and Magoha [15]Mostly surgical ADT, few medical ADTLow-dose stilboestrol
Badmus et al. [19]Surgical ADT (71.9%), medical ADT (24.3%), both (22.2%)Stilboestrol, bicalutamide, goserelin, flutamide5-year overall survival (7.4%)
Yeboah et al. [21]Neoadjuvant hormonotherapy ± medical ADT, EBRT, brachytherapy, TUIP, TURPDocetaxel, LHRH analogue, stilboestrol, bicalutamide /flutamide11% hospital mortality
Ekwere and Egbe [13]Surgical ADT and medical ADTStilboestrol0% 5-year overall survival
Konan et al. [22]Surgical ADT (86.2%), medical ADT (13.7%)Cyproterone acetate, LHRH analogue16.2% mortality
Sow et al. [23]Group 1: surgical ADT and medical ADT only
Group 2: cytoreductive therapy + castration
Group 1: 6-month median (OS)
Group 2: 8-month median (OS)

ADT: androgen deprivation therapy; EBRT: external beam radiation therapy; LHRH: luteinizing hormone-releasing hormone; OS: overall survival; TUIP: transurethral incision of the prostate; TURP: transurethral resection of the prostate. Cytoreductive therapy includes open prostatectomy or TURP.