Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer

Table 2

Univariable and multivariable analyses with Cox proportional hazard model.

	Univariable				Multivariable
Variables	B	Exp(B)	95 CI	P value	B	Exp(B)	95 CI	P value
Age at resection	0.006	1.00	0.94-1.06	0.83
Sex^#	-0.03	0.97	0.30-3.03	0.95
Etiology^# (viral/nonviral)	0.34	1.40	0.55-3.58	0.47
Fibrosis grade^# (0-2/3-4)	-0.68	0.50	0.17-1.41	0.19
Tumor size, cm	-0.82	0.92	0.75-1.12	0.42
Tumor stage^# (I-II/III-IV)	-0.38	0.96	0.30-3.02	0.94
Tumor Multiplicity^#	0.48	1.61	0.51-5.09	0.41
Microvascular invasion^#	-0.50	0.60	0.13-2.69	0.51
Histological differentiation^# (well-to-moderate/poor)	0.48	1.63	0.36-7.22	0.52
Prior TACE/RFA^#	1.36	3.91	1.24-12.32	0.02	1.16	3.18	0.99-10.22	0.05
Type of hepatectomy^#; (major/minor)	-0.38	0.682	0.21-2.14	0.51
INR ≥ 1.0^#	1.77	5.90	0.77-44.94	0.09
AFP > 20 ng/mL^#	0.60	1.83	0.66-5.06	0.24
PIVKA II > 40, mAU/L^#	-0.25	0.77	0.28-2.14	0.62
AST, U/L	0.20	1.01	0.99-1.04	0.09
ALT, U/L	-0.005	0.99	0.97-1.01	0.61
Albumin, g/L	0.20	1.23	0.46-3.24	0.67
TB, mg/dL	0.14	1.15	0.34-3.92	0.81
Preop. platelet count × 10^3/μL	-0.08	0.92	0.83-1.01	0.10
Postop. platelet count × 10^3/μL	-0.15	0.85	0.74-0.99	0.04
Preop. sPDGF-BB^#,; pg/mL	1.33	3.78	1.20-11.94	0.02	0.84	2.32	0.71-7.54	0.16
Postop. sPDGF-BB^#, pg/mL	1.87	6.52	1.82-23.24	0.004	1.73	5.64	1.56-20.30	0.008
Clavien-Dindo severe morbidity^#	-0.77	0.46	0.06-35.0	0.45

ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; TB, total bilirubin; AFP, alpha-fetoprotein; PIVKA II, protein induced by vitamin K absence/antagonist-II; TACE, transarterial chemoembolization; RFA, radiofrequency ablation; INR, international normalized ratio; Preop., preoperative; Postop., postoperative; sPDGF-BB, serum platelet derived growth factor-BB; ^#, categorical variable.