Research Article
Interaction of Anticancer Drugs with Human Organic Anion Transporter hOAT4
Table 1
Physiochemical characteristics of estrone sulfate, epirubicin hydrochloride, and dabrafenib mesylate.
| ā | estrone sulfate | epirubicin hydrochloride | dabrafenib mesylate |
| Molecular weight | 350.43 | 579.99 | 615.65 |
| logP | 3.83 | 0.9 | 5.46 |
| Physiological Charge | -1 | 1 | 0 |
| Hydrogen Acceptor Count | 4 | 12 | 6 |
| Hydrogen Donor Count | 1 | 6 | 2 |
| Polar Surface Area | 80.67 | 206.07 | 110.86 |
| Rotatable Bond Count | 2 | 5 | 5 |
| Polarizability | 36.64 | 53.88 | 49.71 |
| Number of Rings | 4 | 5 | 4 |
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Values are calculated by Chemicalized Platform, ChemAxon, USA.
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