Research Article
Interaction of Anticancer Drugs with Human Organic Anion Transporter hOAT4
Table 1
Physiochemical characteristics of estrone sulfate, epirubicin hydrochloride, and dabrafenib mesylate.
| | | estrone sulfate | epirubicin hydrochloride | dabrafenib mesylate |
| | Molecular weight | 350.43 | 579.99 | 615.65 |
| | logP | 3.83 | 0.9 | 5.46 |
| | Physiological Charge | -1 | 1 | 0 |
| | Hydrogen Acceptor Count | 4 | 12 | 6 |
| | Hydrogen Donor Count | 1 | 6 | 2 |
| | Polar Surface Area | 80.67 | 206.07 | 110.86 |
| | Rotatable Bond Count | 2 | 5 | 5 |
| | Polarizability | 36.64 | 53.88 | 49.71 |
| | Number of Rings | 4 | 5 | 4 |
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Values are calculated by Chemicalized Platform, ChemAxon, USA.
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