Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/<i>p</i>-STAT3 Signaling in Human Breast Cancers

<div>Dovitinib inhibited cell proliferation in a dose- and time-dependent manner. The breast cancer cell lines were treated with dovitinib at the indicated doses for 24 and 48 h, and cell viability was assessed by MTT assay. 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602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,40.505,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.469,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.709,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> (a) HCC1937. (b) MCF-7. (c) MDA-MB-231. (d) MDA-MB-453. (e) MDA-MB-468. (f) SK-BR-3.</div>

Journal of Oncology

fig1

Figure 1

Figure 1: Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/<i>p</i>-STAT3 Signaling in Human Breast Cancers 

Journal of Oncology

Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/p-STAT3 Signaling in Human Breast Cancers

Figure 1