Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/p-STAT3 Signaling in Human Breast Cancers

Figure 5

Dovitinib inhibited pSTAT3, apoptotic signaling pathway. Cells were exposed to drugs for 24 h. Cell extracts were subjected to immunoblot analysis for STAT3, pSTAT3, caspase 9, cyclin D1, PARP, survivin, LC3, and actin. CF: cleavage form.