Dovitinib Triggers Apoptosis and Autophagic Cell Death by Targeting SHP-1/p-STAT3 Signaling in Human Breast Cancers

Figure 7

SHP-1 inhibitor decreased the STAT3-inactivating effect of dovitinib. MCF-7 cells were treated with dovitinib (10 and 15 μmole/L) for 24 h. Cell extracts were subjected to immunoblot analysis for STAT3, pSTAT3, cyclin D1, and actin.