Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Figure 4

miR-485-5p and miR-181c negatively correlated with MCAK expression and associated with better survival in breast cancer. The scatter plots between MCAK and miR-485-5p and miR-181c were shown on (a). The mRNA expression of MCAK was reduced by mimics of miR-485-5p and miR-181c (b). A gene set enrichment analysis for MCAK and signatures of miR-485-5p/miR-181c were also displayed on (c) and (d). Cases were stratified into high and low subgroups based on expression levels of miR-485-5p and miR-181c. The Kaplan-Meier curves of these two microRNAs are shown in (e) and (f). Cox proportional hazard analysis for MCAK, miR-485-5p, miR-181c, tumor size, lymph node involvement, and Elston grade in GSE22220 dataset are shown on (g).

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