Journal of Oncology

Research Article

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Table 1

Uni- and multivariate analysis for MCAK and survival in microarray datasets.
Data set (cases) Overall survival Disease-free survival
HR (95% CI)Adjusted HR (95% CI)HR (95% CI)Adjusted HR (95% CI)
GSE7390     
(n=198)Q1ReferenceReferenceReferenceReference
 Q22.93 (1.19-8.23)†3.14 (1.27-8.84) †2.30 (1.21-4.62) †2.26 (1.18-4.55) †
 Q34.84 (2.09-13.12) ‡4.89 (1.96-13.94) ‡3.41 (1.82-6.76) ‡3.67 (1.85-7.62) ‡
 Q42.32 (0.90-6.81)1.72 (0.60-5.75)1.65 (0.82-3.41)1.85 (0.80-4.35)
GSE2034     
(n=286)Q1N/AN/AReferenceReference
 Q2  1.56 (0.86-2.89)1.55 (0.86-2.88)
 Q3  2.13 (1.21-3.87) ‡2.26 (1.27-4.13) ‡
 Q4  2.19 (1.24-4.00) ‡2.47 (1.35-4.62) ‡
GSE1456     
(n=159)Q1ReferenceReferenceReference Reference
 Q210.1 (1.90-187) ‡1.6e+91.8e+91.5e+9
(4.06-2.7e+305) ‡(6.03-6.6e+179) ‡(4.55-9.0e+304) ‡
 Q321.7 (4.46-392) ‡3.1e+92.9e+92.2e+9
(7.91-3.6e+122) ‡(9.71-1.5e+254) ‡(6.58-1.8e+34) ‡
 Q415.2 (3.03-276) ‡1.9e+92.5e+91.4e+9
(4.59-6.9e+100) ‡(8.38-6.3e+55) ‡(3.81-1.2e+137) ‡
GSE4922     
(n-289)Q1N/AN/AReferenceReference
 Q2  1.25 (0.65-2.41)1.23 (0.63-2.43)
 Q3  1.99 (1.08 -3.76)†1.82 (0.95-3.56)
 Q4  2.33 (1.28-4.36) ‡1.65 (0.79-3.50)
GSE22226     
(n=129)Q1ReferenceReferenceReferenceReference
 Q20.71 (0.14-3.32)0.92 (0.17-4.99)0.83 (0.29-2.31)0.68 (0.20-2.15)
 Q32.24 (0.70-8.38)1.73 (0.47-8.30)1.27 (0.49-3.39)1.10 (0.39-3.24)
 Q43.94 (1.37-14.1) ‡2.49 (0.71-11.7)2.95 (1.30-9.27) ‡2.18 (0.84-6.15)
GSE24450     
(n=183)Q1ReferenceN/AReferenceN/A
 Q20.60 (0.12-2.44) 0.50 (0.10-1.89) 
 Q32.07 (0.74-6.66) 1.86 (0.69-5.47) 
 Q44.29 (1.72-12.9) ‡ 4.23 (1.80-11.6) ‡ 
GSE53031     
(n=167)Q1N/AN/AReferenceReference
 Q2  3.58 (1.30-12.6) †2.87 (1.01-10.3) †
 Q3  2.88 (1.00-10.3) †1.99 (0.66-7.33)
 Q4  2.91 (0.99-10.5)1.30 (0.39-5.16)
GSE25066     
(n=198)Q1N/AN/AReferenceReference
 Q2  2.13 (0.67-7.84)1.62 (0.49-6.25)
 Q3  5.03 (1.86-17.49) ‡3.86 (1.33-14.2) †
 Q4  4.54 (1.66-15.84) ‡2.55 (0.80-10.1)
GSE10885     
(n=237)Q1ReferenceReferenceReferenceReference
 Q21.79 (0.70-4.89)1.43 (0.49-4.50)0.85 (0.35-2.02)0.95 (0.36-2.44)
 Q31.75 (0.65-4.91)1.21 (0.40-3.79)1.95 (0.94-4.22)1.75 (0.77-4.17)
 Q42.68 (1.18-6.85) †2.01 (0.74-6.13)1.97 (0.98-4.13)1.77 (0.75-3.47)
GSE58812     
(n=107)Q1ReferenceReferenceReferenceReference
 Q20.73 (0.24-2.10)0.83 (0.27-2.42)1.39 (0.48-4.22)1.54 (0.53-4.70)
 Q31.13 (0.45-2.96)1.39 (0.54-3.69)1.84 (0.70-5.33)2.22 (1.02-7.63)
 Q40.55 (0.17-1.66)0.67 (0.20-2.01)0.91 (0.29-2.99)1.10 (0.34-3.55)
NKI set     
(n=295)Q1ReferenceReferenceReferenceReference
 Q23.56 (1.28-12.57) †2.64 (0.92-8.48)1.87 (0.99-3.70)1.60 (0.83-3.21)
 Q39.12 (3.60-30.71) ‡5.47 (2.07-18.9) ‡3.89 (2.17-7.40) ‡2.95 (1.59-5.80) ‡
 Q411.16 (4.41-37.54)‡4.39 (1.53-16.0) ‡3.95 (2.19-7.55) ‡2.37 (1.17-5.00) †
TCGA1     
(n=526)Q1ReferenceReferenceReferenceReference
 Q20.68 (0.36-1.27)0.74 (0.39-1.38)1.32 (0.63-2.84)1.39 (0.66-3.07)
 Q31.01 (0.55-1.84)1.17 (0.63-2.16)0.76 (0.30-1.84)0.79 (0.30-1.96)
 Q40.94 (0.52-1.70)1.01 (0.50-2.02)1.67 (0.83-3.51)4.25 (0.78-4.25)
TCGA2     
(n=1903)Q1ReferenceReferenceNANA
 Q21.99 (1.53-2.61) ‡1.88 (1.43-2.50) ‡  
 Q32.50 (1.94-3.26) ‡2.08 (1.57-2.78)‡  
 Q43.00 (2.33-3.89)‡2.20 (1.63-2.99) ‡  
Pooled GEO     
(n=2248)Q1ReferenceReferenceReferenceReference
 Q21.83 (1.22-2.80) ‡2.04 (1.20-3.60) ‡1.64 (1.28-2.11)‡1.54 (1.34-2.09) ‡
 Q33.55 (2.45-5.27) ‡3.13 (1.87-5.47) ‡2.66 (2.11-3.38)‡2.30 (1.71-3.14) ‡
 Q43.77 (2.61-5.59)‡2.27 (1.30-4.11) ‡2.66 (2.11-3.38)‡1.82 (1.31-2.54)‡
Pooled TCGA     
(n=2429)Q1ReferenceReferenceReferenceReference
 Q21.71 (1.35-2.19) ‡1.85 (1.41-2.45) ‡1.32 (0.63-2.84)1.40 (0.66-3.07)
 Q32.18 (1.73-2.77) ‡2.08 (1.57-2.77) ‡0.76 (0.30-1.84)0.79 (0.30-1.96)
 Q42.55 (2.03-3.22)‡2.22 (1.65-3.01) ‡1.67 (0.83-3.51)1.79 (0.78-4.25)
      
Note: uni- and multivariate analyses were conducted to evaluate HR of MCAK.
For multivariate analysis, HR was adjusted by age, ER status, and Elston Grade in GSE7390, GSE4922, and GSE25066 and in pool analysis datasets. In the GSE2034 set, HR was adjusted by ER status and it was adjusted by age and ER status in GSE58812. The probe of MCAK was 209408_s_at.
HR was adjusted by age, ER status, and Elston Grade in GSE10885 and GSE22226 sets, in which the probe of MCAK was A_23_P34788.
The probe of MCAK was ILMN_1779153 in GSE24550.
HR was adjusted by age, ER status, and Elston Grade in the GSE53031 set, in which the probe of MCAK was 11745868_a_at.
† Statistical significance, P<0.05; ‡ Statistical significance, P<0.01.