Formation of Polyploid Giant Cancer Cells Involves in the Prognostic Value of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer

Figure 2

(a) Time-lapse observation of cultured LoVo and HCT116 cells after irradiation (40x): (A and F) morphologic characteristics of LoVo and HCT116 before irradiation (B and G), 7 days after irradiation (C and H), 11 days after irradiation (D and I), 14 days after irradiation (E and J), and 18 days after irradiation. (b) Time-lapse observation of LoVo after chemotherapeutic treatment (40x): (A) 2 days after capecitabine treatment, (B) 11 days after capecitabine treatment, (C) 18 days after capecitabine treatment, (D) 2 days after a second capecitabine treatment, (E) 2 days after oxaliplatin treatment, (F) 11 days after oxaliplatin treatment, (G) 18 days after oxaliplatin treatment, (H) 2 days after a second oxaliplatin treatment, (I) 2 days after irinotecan treatment, (J) 11 days after irinotecan treatment, (K) 18 days after irinotecan treatment, and (L) 2 days after a second irinotecan treatment. (c) Time-lapse observation of HCT116 after chemotherapeutic treatment (40x): (A) 2 days after capecitabine treatment, (B) 11 days after capecitabine treatment, (C) 18 days after capecitabine treatment, (D) 2 days after a second capecitabine treatment, (E) 2 days after oxaliplatin treatment, (F) 11 days after oxaliplatin treatment, (G) 18 days after oxaliplatin treatment, (H) 2 days after a second oxaliplatin treatment, (I) 2 days after irinotecan treatment. (J) 11 days after irinotecan treatment, (K) 18 days after irinotecan treatment, and (L) 2 days after a second irinotecan treatment.

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