Formation of Polyploid Giant Cancer Cells Involves in the Prognostic Value of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer

Table 3

Clinicopathological characteristics in 304 cases of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation therapy (nCRT).

	AJCC and CAP regression score					Chi-square	value
	Total	CR	PR	SD	PD
Number of patients	304	29 (9.54%)	125 (41.12%)	138 (45.39%)	12 (3.95%)
Age (years), mean	60.02	61.09	59.40	59.61	66.58	4.830	0.185
Sex
Male	206 (67.76%)	20 (9.71%)	85 (41.26%)	92 (44.66%)	9 (4.37%)
Female	98 (32.24%)	9 (9.18%)	40 (40.82%)	46 (46.94%)	3 (3.06%)	0.3355	0.953
Rest interval (d), mean	68.46	69.10	55.29	72.97	152.17	6.733	0.081
Pathology N stage^◆						440.120	0.001
Complete response	27 (8.91%)	25 (92.59%)	2 (7.41%)	0	0
T1	9 (2.97%)	0	8 (88.89%)	1 (11.11%)	0
T2	43 (14.19%)	1 (2.33%)	25 (58.14%)	17 (39.53%)	0
T3	197 (65.02%)	3 (1.52%)	83 (42.13%)	111 (56.35%)	0
T4	27 (8.91%)	0	6 (22.22%)	9 (33.33%)	12 (44.44%)
Pathology N stage						18.007	0.001
N0	184 (65.02%)	27 (14.67%)	80 (43.48%)	77 (41.85%)	0
N1	72 (25.44%)	0	25 (34.72%)	47 (65.28%)	0
N2	27 (9.54%)	2 (7.41%)	12 (44.44%)	13 (48.15%)	0
Histological type^▼						24.617	0.001
Mucinous carcinoma	59 (21.22%)	11 (18.64%)	27 (45.76%)	21 (35.59%)	0
Nonmucinous carcinoma	219 (78.78%)	5 (2.28%)	97 (44.29%)	117 (53.42%)	0
Histological differentiation^△						1.781	0.411
Well + moderately	190 (88.79%)	3 (1.58%)	86 (45.26%)	101 (53.16%)	0
Poor	24 (11.21%)	0	8 (33.33%)	16 (66.67%)	0

^◆1 missing value; 21 missing values; ^▼26 missing values; ^△90 missing values. CR, complete remission; PR, partial remission; PD, progressive disease; SD, stable disease; AJCC, American Joint Committee on Cancer; CAP, College of American Pathologists; nCRT, neoadjuvant chemoradiation therapy.