Noninvasive Identification of Immune-Related Biomarkers in Hepatocellular Carcinoma

Table 1

Gene ontology analysis of differentially expressed genes associated with hepatocellular carcinoma.

	Category	Term	Count	%	value
Upregulated	GOTERM_BP_DIRECT	GO:0045766∼positive regulation of angiogenesis	5	<0.001	<0.001
	GOTERM_BP_DIRECT	GO:0008285∼negative regulation of cell proliferation	5	0.01	0.01
	GOTERM_BP_DIRECT	GO:0008284∼positive regulation of cell proliferation	5	0.02	0.02
	GOTERM_BP_DIRECT	GO:0007052∼mitotic spindle organization	3	<0.001	<0.001
	GOTERM_BP_DIRECT	GO:0030593∼neutrophil chemotaxis	3	0.02	0.02
	GOTERM_CC_DIRECT	GO:0005634∼nucleus	20	0.12	0.01
	GOTERM_CC_DIRECT	GO:0005654∼nucleoplasm	11	0.07	0.02
	GOTERM_CC_DIRECT	GO:0031091∼platelet alpha granule	2	0.01	0.04
	GOTERM_CC_DIRECT	GO:0005615∼extracellular space	9	0.06	0.05
	GOTERM_MF_DIRECT	GO:0000166∼nucleotide binding	5	0.03	0.04
	GOTERM_MF_DIRECT	GO:0031625∼ubiquitin protein ligase binding	3	0.02	0.05
Downregulated	GOTERM_BP_DIRECT	GO:0006915∼apoptotic process	9	0.06	0.02
	GOTERM_BP_DIRECT	GO:0006955∼immune response	8	0.05	0.02
	GOTERM_BP_DIRECT	GO:0006954∼inflammatory response	7	0.04	0.03
	GOTERM_BP_DIRECT	GO:0007267∼cell-cell signaling	6	0.04	0.05
	GOTERM_BP_DIRECT	GO:0051092∼positive regulation of NF-kappaB transcription factor activity	6	0.04	<0.001
	GOTERM_CC_DIRECT	GO:0005829∼cytosol	33	0.21	0.01
	GOTERM_CC_DIRECT	GO:0070062∼extracellular exosome	26	0.16	0.04
	GOTERM_CC_DIRECT	GO:0000139∼golgi membrane	9	0.06	0.03
	GOTERM_CC_DIRECT	GO:0072562∼blood microparticle	6	0.04	<0.001
	GOTERM_CC_DIRECT	GO:0000784∼nuclear chromosome, telomeric region	4	0.03	0.05
	GOTERM_MF_DIRECT	GO:0005102∼receptor binding	7	0.04	0.03
	GOTERM_MF_DIRECT	GO:0005506∼iron ion binding	5	0.03	0.02
	GOTERM_MF_DIRECT	GO:0031720∼haptoglobin binding	3	0.02	<0.001
	GOTERM_MF_DIRECT	GO:0005344∼oxygen transporter activity	3	0.02	<0.001
	GOTERM_MF_DIRECT	GO:0004601∼peroxidase activity	3	0.02	0.01