The Role of Tumor-Infiltrating B Cells in Tumor Immunity

Figure 1

The subtypes of TIB and its dual effects on tumor. The differentiation of TIB subtypes and tumor tissue infiltration of TIB are regulated by tumor microenvironment. TIB can not only inhibit tumor development by secreting cytokines, antigen presentation, and secreting antibodies but also promote tumor progress by differentiation into Bregs, acting on tumor cells or inhibiting the function of NK and T cells and promoting the transformation of Tregs. The arrows represent the promotion effects, and the blunt ends represent the inhibition effects. The unilateral arrows represent transformation. The vertical intersection of multiple lines in the same line indicates that it points to the end of the same arrow or the end of the same blunt end.