Human Papillomavirus Infection and Cervical Cancer: Epidemiology, Screening, and Vaccination—Review of Current Perspectives

Figure 1

Progression of cervical cancerogenesis which involves HPV gene integration, leading to sustained expression of E6 and E7, impacting and dysregulating the various pathways including the inactivation and degradation of p53 and pRB that lead to uncontrolled cellular division, proliferation, tumor suppressor evasion, and other features of tumorigenicity.