Research Article

Prognostic Value of CD133 and SOX2 in Advanced Cancer

Table 1

Main characteristics of studies included in the meta-analysis.

First authorStudy sourceAgeTesting methodCancer typeStudy designSpecimen typeCasesSurvival rateOutcomesTherapy

Mehra 2006The NetherlandsNANASBACancer with bone metastasesRetrospective, multicentreBlood50< 3 yearsOSPart (adjuvant therapy)

Li 2009ChinaNAIHCAdvanced colon carcinomaRetrospective, single-centerTissue1045 yearsOSAdjuvant chemotherapy

Fusi 2011Germany54Flow cytometry analysisMetastatic melanomaRetrospective, single-centerBlood32NAOSNeoadjuvant chemotherapy

Pilati 2012Italy63qRT-PCRColorectal liver metastasisRetrospective, single-centerBlood503 yearsCSSSurgery and chemotherapy

Sakai 2012JapanNAIHCColorectal cancer with liver metastasisRetrospective, single-centerTissue923 yearsOS, DFSSurgery

Qin 2012ChinaNAIHCAdvanced serous ovarian cancerRetrospective, multicentreTissue123NAOSAdjuvant chemotherapy

Lee 2012Korea61.5IHCAdvanced gastric cancerRetrospective, single-centerTissue1005 yearsOS, DFSSurgery and adjuvant chemotherapy

Sprenger 2013Germany63IHC, blindAdvanced rectal adenocarcinomaProspective, multicentreTissue126NACSS, DFSSurgery and radiochemotherapy

Yamamoto 2014JapanNAIHC, blindColorectal cancer liver metastasisRetrospective, single-centerTissue1035 yearsOSSurgery and chemotherapy

Liu 2014China57IHC, blindEpithelial ovarian cancer with central nervous system metastasisRetrospective, single-centerTissue29< 3 yearsOSSurgery and adjuvant therapy

Kazama 2015Japan67.1IHCColorectal cancer with lymph node metastasisRetrospective, single-centerTissue138> 5 yearsOSSurgery and adjuvant chemotherapy

Kishikawa 2016Japan59.4IHCColorectal cancer with synchronous liver metastasesRetrospective, single-centerTissue88NAOS, DFSSurgery and adjuvant chemotherapy

Pei 2016ChinaNAIHC, blindAdvanced colorectal cancerRetrospective, single-centerTissue323NAOS, DFSSurgery and adjuvant chemotherapy

Huang 2014ChinaNAIHC, blindBreast cancer with axillary lymph nodesRetrospective, multicentreTissue107NADFSNA

Shen 2014China51IHC, blindAdvanced cervical squamous cell carcinomaRetrospective, multicentreTissue1325 yearsPFSRadiotherapy

Udagawa 2015Japan66IHCLung squamous cell carcinoma with lymph node metastasisRetrospective, single-centerTissue113NARFSSurgery

Sodja 2016Slovenia65qRT-PCRAdvanced small-cell lung cancerProspective, single-centerBlood50NADFS, PFSChemotherapy

Yamawaki 2017JapanNAIHCAdvanced endometrial cancerRetrospective, single-centerTissue31NAPFSNA

NA: not applicable; NASBA: nuclear acid sequence-based amplification; IHC: immunohistochemistry; qRT-PCR: Real-Time Quantitative PCR; OS: overall survival; DFS: disease-free survival; PFS: progression-free survival; CSS: cancer-specific survival; RFS: recurrence-free survival (RFS).