A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Figure 4

CTSS gene expression is highest in BR300 TNBC subtype and associated with DNA damage/cell cycle pathways. CTSS gene expression was evaluated using an in house dataset containing 300 breast cancer patients. Analysis revealed (a) CTSS expression to be highest in TNBC. (b) Lehman subgroups analysis of the TNBC patients revealed an association with the BL1 group which encompasses DNA damage and cell cycle pathways. Significance for both panels was determined by one-way ANOVA. <0.05, <0.01, and <0.001.

(a)

(b)