A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer
Epithelial cell CTSS expression in TNBC patients is associated with an M1 macrophage phenotype. Immunohistochemical epithelial CTSS scores were matched with (a) macrophage marker CD68, (b) M1 polarisation marker CD14 and (c) M2 polarisation marker CD163. Shading indicates proportion of IHC score for each marker. Statistical significance determined by Chi-Square analysis. Macrophage polarisation was analysed using gene expression algorithms and correlated with CTSS IHC expression generating (d) M2/M1 and (e) CD68/CD8 signature scores. Statistical significance determined by one-way ANOVA. N=number of patients. <0.05, <0.01, and <0.001.
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