Research Article

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Table 1

Clinicopathological information for BR300 tissue microarray categorised according to compartmental CTSS scores. CTSS scores of 0 and 1 behaved similarly in terms of survival, as were patients with CTSS scores of 2 and 3. Patients were therefore stratified based on low CTSS (score of 0 and 1) or high CTSS (score of 2 and 3) expression. Differences between clinical information was evaluated based on high and low CTSS scores in either the epithelial and stromal compartments. Statistical significance determined by Chi-Square test. Figure in brackets indicates percentage of total. LVI=lymphovascular invasion. N=number of patients.

BR300 CohortCTSS EpithelialCTSS Stromal
N (%)Low (%)High (%)p-valueN (%)Low (%)High (%)p-value

Characteristic267 (100)221 (100)46 (100)262 (100)79 (100)183 (100)

AgeN≤51140 (52)113 (51)27 (59)140 (53)41 (52)99 (54)
Median = 51N>51127 (48)108 (49)19 (41)0.42122 (47)38 (48)84 (46)0.79

Grade14 (1)4 (2)0 (0)4 (2)3 (4)1 (1)
2106 (40)99 (45)7 (15)103 (39)45 (57)58 (32)
3157 (59)118 (53)39 (85)155 (59)31 (39)124 (68)<

Tumour154 (20)45 (20)9 (20)54 (21)14 (18)40 (22)
2171 (64)146 (66)25 (54)166 (63)52 (66)114 (62)
336 (13)24 (11)12 (26)36 (14)11 (14)25 (14)
4/4b6 (2)6 (3)0 (0)6 (2)2 (3)4 (2)0.9

Node0114 (43)86 (39)28 (61)113 (43)33 (42)80 (44)
193 (35)83 (38)14 (30)91 (35)26 (33)64 (35)
234 (13)31 (14)3 (7)33 (13)13 (16)20 (11)
326 (10)25 (11)1 (2)26 (10)7 (9)19 (10)0.66

LVIYes168 (63)145 (66)23 (50)164 (63)51 (65)113 (62)
No96 (36)73 (33)23 (50)96 (37)26 (33)70 (38)
Unknown3 (1)3 (1)0 (0)0.0763 (1)2 (3)1 (1)0.3

HistologyDuctal210 (79)172 (78)38 (83)207 (79)49 (62)158 (86)
Lobular27 (10)24 (11)3 (7)26 (10)16 (20)10 (5)
Mixed24 (9)21 (10)3 (7)23 (9)12 (15)11 (6)
Other6 (2)4 (2)2 (4)0.526 (2)2 (3)4 (2)<

RadiotherapyYes220 (82)182 (82)38 (83)215 (82)70 (89)145 (79)
No47 (18)39 (18)8 (17)1.0047 (18)9 (11)38 (21)0.080

HormoneYes157 (59)147 (67)10 (22)157 (60)65 (82)88 (48)
TherapyNo110 (41)74 (33)36 (78)<109 (42)14 (18)95 (52)<