ANXA2 Silencing Inhibits Proliferation, Invasion, and Migration in Gastric Cancer Cells

Table 4

KEGG analysis of ANXA2 in the database.

Biological process	No. of genes	P-value	Related genes
Pathways in cancer	224	<0.005	APPL1, FZD10, LPAR6, GNA13, CXCL12, ABL1, PIK3R5, AKT3, MTOR, STAT5A, ARAF, BCL2, SMAD4, TGFBR1, MSH3, PIAS2…
Focal adhesion	122	<0.005	EGF, EGFR, PIK3R5, ITGA11, LAMC3, PAK4, DOCK1, ROCK1, GRF2, MAPK8, JUN, BLC2, ELK1, BRAF, RAPGEF1, CRK, SOS1…
HIF 1 signaling pathway	67	<0.005	AKT2, AKT3, ANGPT1, ARNT, BCL2, CAMK2A, CAMK2B, EGLN1, ENO3, EP300, EPO, PIK3CD, PIK3CG, TEK, TF, VHL…
Proteoglycans in cancer	116	<0.005	ELK1, ROCK1, TIAM1, ITPR1, DROSHA, HOXD10, PIK3R5, AKT3, PDPK1, MTOR, PDCD4, COL21A1, ARAF, HGF, FRS2, SOS1, WNT16…
Regulation of actin cytoskeleton	118	<0.005	F2, GNA13, ARAF, PIK3R5, SOS1, EGFR, EGF, ITGA11, CHRM1, FGD1, VAV3, MSN, ACTN4, MYLK, MYH9, CFL1, ENAH, WASF1…
Central carbon metabolism in cancer	42	<0.005	AKT2, FGFR1, FLT3, GCK, KIT, MTOR, NRAS, NTRK1, NTRK3, PDGFRA, PFKM, PGAM2, PIK3CD, RET…
Vascular smooth muscle contraction	76	<0.005	ACTA2, ADRA1A, AGTR1, BRAF, CACNA1C, EDNRA, GNA12, GNAS, ITPR1, KCNMA1, MRVI1, PLA2G12A, PLCB4, RAMP3, ROCK1…

∗For the “Biological process” column, we showed the function of ANXA2 in gastric cancer tissue. The “No. of genes” column showed the number of genes that enriched in corresponding pathways, and the details were in the “Related genes” column. Correlation statistics were calculated by the R2 platform.