Journal of Oncology / 2019 / Article / Tab 2

Research Article

Complications of Intrathecal Chemotherapy in Adults: Single-Institution Experience in 109 Consecutive Patients

Table 2

Adverse neurologic events.

No. of patients affected (%)No. of Events ( occurrence rate per IT treatment)TreatmentRR95% CIP Value

Significant Neuro Events9 (8.26)11 (3.10)

OverallMTX1--
CYT1.670.19-14.270.641
MTX and CYT1.160.50-2.710.728

Paresthesias8 (7.34)10 (2.82)

MTX1--
CYT1.670.19-14.270.64
MTX and CYT0.640.17-2.390.51

Paralysis2 (1.83)3 (0.85)

MTX1--
CYT8.330.52-133.230.134
MTX and CYT0.800.05-12.820.876

Minor Events29 (26.61)109 (30.70)

OverallMTX1--
CYT1.530.75-3.120.241
MTX and CYT0.970.66-1.410.857

Asthenia4 (3.67)10 (2.82)

MTX1--
CYT2.780.56-13.760.21
MTX and CYT0.800.26-2.490.703

Headache15 (13.76)50 (14.08)

MTX1--
CYT1.230.43-3.530.694
MTX and CYT0.680.39-1.190.180

Back pain9 (8.26)18 (5.07)

MTX1--
CYT2.080.44-9.810.353
MTX and CYT1.000.40-2.540.996

Fever5 (4.59)19 (5.35)

MTX1--
CYT2.780.56-13.780.211
MTX and CYT1.470.54-3.980.447

Nausea13 (11.93)48 (13.52)

MTX1--
CYT0.930.21-3.990.918
MTX and CYT1.250.69-2.260.464

Vomiting6 (5.50)32 (9.01)

MTX1--
CYT1.110.25-4.860.889
MTX and CYT0.910.45-1.820.788

Multiple major or minor events simultaneously are counted only once in overall (overall numbers are therefore less than total of subcategories).
One patient had both paresthesias and paralysis in two events. To avoid double-counting, these events were included only in paresthesias for the RR calculation.

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