Quantitative Volumetric Assessment of Ablative Margins in Hepatocellular Carcinoma: Predicting Local Tumor Progression Using Nonrigid Registration Software
Table 2
Characteristics of patients technically feasible for quantitative analysis.
Total
No LTP
LTP
n
n
n
value
Total
18
10
8
Age
Mean (SD)
64.9 (9.0)
66.1 (10.7)
63.4 (6.5)
0.538
Sex
Male
14
77.8%
7
70.0%
7
87.5%
0.375
Female
4
22.2%
3
30.0%
1
12.5%
Cirrhosis presence
Yes
18
100.0%
10
100.0%
8
100.0%
No
0
0.0%
0
No
0
0.0%
Ascites presence
Yes
5
27.8%
3
30.0%
2
25.0%
0.814
No
13
72.2%
7
70.0%
6
75.0%
Etiology
Hepatitis B
0
0
0
0.800
Hepatitis C
4
2
2
0.410
Alcohol abuse
5
2
3
0.180
NASH
2
2
0
0.250
ECOG
0
17
94.4%
10
100.0%
7
87.5%
0.250
1
1
5.6%
0
No
1
12.5%
Child–Pugh score
A
9
50.0%
5
50.0%
4
50.0%
1.000
B
9
50.0%
5
50.0%
4
50.0%
BCLC
Very early
6
33.3%
3
30.0%
3
37.5%
0.737
Early
12
66.7%
7
70.0%
5
62.5%
Lesion size
Median in mm (range)
22 (12–27)
22 (12–27)
22 (16–25)
OLTx <18 months
Yes
6
33.3%
3
30.0%
3
37.5%
0.737
No
12
66.7%
7
70.0%
5
62.5%
Distant intrahepatic recurrence
Yes
1
5.6%
1
10.0%
0
0.0%
0.357
No
17
94.4%
9
90.0%
8
100.0%
RFA on target quantitative assessment
Yes
6
33.3%
6
60.0%
0
0.0%
0.013
No
12
66.7%
4
40.0%
8
100.0%
RFA on target qualitative assessment
Yes
16
88.9%
10
100.0%
6
75.0%
0.094
No
2
11.1%
0
2
25.0%
Year of RFA
2009–2011
7
38.9%
2
20.0%
5
62.5%
0.066
2012–2014
11
61.1%
8
80.0%
3
37.5%
NASH = nonalcoholic steatohepatitis; ECOG = Eastern Cooperative Oncology Group; BCLC = Barcelona Clinic for Liver Cancer; RFA = radiofrequency ablation. More etiological factors could be present in one patient.
