The CTLH Complex in Cancer Cell Plasticity

Figure 1

Schematic representation of the 11 members of the mammalian CTLH complex. Except for ARMC8, GID4, and YPEL5, all the other members present a LisH domain followed by a defining CTLH domain. Both LisH and CTLH domains are considered protein-protein interaction domains. MAEA in association with RMND5A or RMND5B provides the E3-ligase enzymatic activity of the complex. RANBP9 and RANBP10 are collectively called Scorpins (Spry-COntaining Ran binding ProteINS).