The CTLH Complex in Cancer Cell Plasticity

Figure 2

Schematic representation of the CTLH complex. The mammalian CTLH complex is a heterodecameric multimolecular structure built on dimer of GID8 (DARK RED). Its core (RED) includes the heterodimer MAEA-RMND5A or MAEA-RMND5B that together provide the E3-ligase enzymatic activity, the Scorpins (RANBP9, RANBP10), and WDR26. Peripheral components (GREEN) are GID4, ARMC8, MKLN1, and YPEL5.