The CTLH Complex in Cancer Cell Plasticity

Figure 3

CTLH gene alterations in the most prevalent malignancies in the USA. The TCGA collection of the top 5 most prevalent malignancies in the USA reported in Table 2 was queried for alterations pertaining the 11 CTLH genes (http://www.cbioportal.org). (a) About 5% of cases show mutations of the CTLH genes. (b) For all the analyzed genes, the vast majority of mutations are missense and their functional significance is unknown. (c) 13% of cases show putative copy number variations (CNVs) of the CTLH genes. (d) Putative amplifications are overwhelmingly more prevalent than copy number losses of ARMC8, GID8, RMND5B, WDR26, and YPEL5. On the other hand, GID4, MAEA, and RANBP10 display more copy number losses than gains. (e) 61% of cases show alteration of expression concerning the CTLH genes. (f) Cases of overexpression are overwhelmingly more prevalent than underexpression with the exception of GID4.

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