Research Article

Colon Cancer Sidedness, Presentation, and Survival at Different Stages

Table 3

Independent predictors of overall survival (OS) for colon cancer.

CharacteristicsAdjusted HR (95% Confidence Interval)P-value

Male1.18 (1.16-0.1.20)<0.001

Race
Hispanic (ref)
Black1.15 (1.11-1.20)<0.001
White1.06 (1.02-1.09)<0.001
Others0.89 (0.85-0.92)<0.001

Age
<50 (ref)
50-691.26 (1.22-1.30)<0.001
70-892.60 (2.47-2.64)<0.001

Insurance
Insured (ref)
Medicaid1.39 (1.36-1.43)<0.001
Insured/no specifics1.14 (1.11-1.16)<0.001
Uninsured1.31 (1.25-1.37)<0.001
Unknown1.06 (1.00-1.13)0.062

Marital status
Married (ref)
Divorced1.21 (1.18-1.25)<0.001
Separated1.17 (1.08-1.26)<0.001
Single1.29 (1.26-1.32)<0.001
Unknown1.12 (1.07-1.17)<0.001
Widowed1.38 (1.35-1.42)<0.001

Geographic region
Northeastern (ref)
Midwestern1.08 (1.05-1.12)<0.001
Western1.06 (1.03-1.08)<0.001
Southern1.14 (1.11-1.17)<0.001

AJCC6th edition
Stage I (ref)
II1.30 (1.26-1.34)<0.001
III2.06 (2.00-2.12)<0.001
IV7.88 (7.63-8.13)<0.001

Tumor Grade
Grade I (Ref)
grade II1.08 (1.04-1.12)<0.001
grade III 1.47 (1.41-1.53)<0.001
grade IV1.58 (1.49-1.68)<0.001
Unknown 1.18 (1.13-1.24)<0.001

Histology
Mucinous adenocarcinoma (ref)
Adenocarcinoma NOS0.90 (0.87-0.92)<0.001
Signet ring cell carcinoma1.37 (1.28-1.47)<0.001
Adenocarcinoma in adenomatous polyps 0.74 (0.71-0.78)<0.001
Others (papillary, adenosquamous, medullary)0.82 (0.79-0.86)<0.001

Treatment
No surgery (ref)
Surgery performed0.39 (0.38-0.40)<0.001

Laterality
Right sided (ref)
Left sided0.87 (0.85-0.88)<0.001

ref = reference; HR = hazard ratio.