Journal of Oncology / 2019 / Article / Tab 1

Review Article

DNA Repair Deficiency in Breast Cancer: Opportunities for Immunotherapy

Table 1

DNA repair pathways mutated in breast cancer and potential therapeutic interventions.

DNA Repair PathwayDefective mutation in Breast CancerTherapeutic Intervention

Homologous recombinationBRCA1, BRCA2, ATM, ATR, CHK1, CHK2, BARD1, RAD51D, NBS1, PALB2, FANCD2, CtIP, PALB2 [17, 5154]Platinum based chemotherapies [55], PARP inhibitors (immune checkpoint blockade)

Non-homologous end-joiningDNA-PK, KU70/80 [56]DNAPK inhibitors, ionizing radiation

Mismatch repairMLH1, MSH2, MSH6, PMS2 [57, 58]Immune checkpoint blockade

Base excision repair, Nucleotide excision repair,  
Translesional synthesis
APE1, XRCC1, ERCC2 [59, 60]APE1 inhibitors [61]

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.