Table 2: Univariate and multivariate analyses of CSS in ESCC patients.

Univariate analysisP-valueMultivariate analysisP-value
HR (95% CI)HR (95% CI)

Age (years)0.584
 ≤ 601.000
 > 600.930 (0.717-1.206)
Gender0.530
 Female1.000
 Male1.105 (0.809-1.510)
Tumor length (cm)0.001
 ≤ 3.01.000
 > 3.01.634 (1.208-2.211)
Tumor location0.845
 Upper1.000
 Middle1.160 (0.624-2.156)0.638
 Lower1.197 (0.644-2.222)0.569
Vessel invasion0.003
 Negative1.000
 Positive1.636 (1.187-2.255)
Differentiation0.075
 Well1.000
 Moderate1.247 (0.834-1.864)0.282
 Poor1.660 (1.045-2.638)0.032
CRP (mg/L)<0.001
 ≤ 10.51.000
 > 10.51.896 (1.450-2.479)
ALB (g/L)0.002
 ≤ 40.51.000
 > 40.50.669 (0.517-0.867)
PALB (mg/L)<0.001
 ≤ 2481.000
 > 2480.613 (0.474-0.792)
CPR<0.0010.008
 ≤ 0.031.0001.000
 > 0.032.116 (1.634-2.739)1.630 (1.135-2.342)
CAR<0.0010.052
 ≤ 0.31.000
 > 0.31.485 (0.997-2.212)
Adjuvant therapy1.0000.329
 No1.149 (0.870-1.517)
 Yes
TNM stage<0.001<0.001
 I1.0001.000
 II1.804 (1.237-2.631)0.0021.628 (1.111-2.387)0.012
 III3.067 (2.150-4.373)<0.0012.559 (1.786-3.667)<0.001
BMI (kg/m2)
 ≥ 201.000<0.0011.000<0.001
 < 202.006 (1.551-2.595)1.877 (1.444-2.440)

ESCC: esophageal squamous cell carcinoma; CRP: C-reactive protein; PALB: prealbumin; ALB: albumin; CPR: C-reactive protein to prealbumin ratio; CAR: C-reactive protein to albumin ratio; TNM: tumor, node, metastasis; BMI: body mass index; CI: confidence interval; HR: hazard ratio.