A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements

Table 1

Odds ratios for TNBC for loci identified in more than one study.

Location	Gene	SNP	Risk Allele	OR/HR	95% CI	P-value	Reference
1q32	MDM4	rs4245739	C	1.18	1.13-1.23	4.3x10^−15	[15]
			C	1.17	1.09-1.26	3.1x10^−5	[16]
			C	1.19	1.11-1.29	4.0x10^−6	[17]
2q35		rs13387042	G	0.93	0.87-1.00	0.049	[17]
			G	1.12	1.05-1.21	0.001	[18]
5p15	TERT	rs10069690	A	1.28	1.23-1.33	2.4x10^−33	[15]
			A	1.24	1.14-1.34	1.4x10^−7	[17]
			A	1.25	1.16-1.34	1.1x10^−9	[19]
			A	1.27	1.20-1.36	5.2x10^−14	[20]
		rs2736108	T	0.77	0.69-0.87	8.3x10^−6	[17]
6q25	ESR1	rs2046210	A	1.16	1.08-1.24	5.3x10^−5	[17]
			A	1.23	1.16-1.31	5.5x10^−12	[20]
			A	1.29	1.17-1.42	4.4x10^−7	[21]
		rs3757318	A	1.33	1.17-1.51	9.3x10^−6	[17]
		rs12662670	G	1.33	1.15-1.53	1.1x10^−4	[21]
14q24	RAD51L1	rs999737	T	0.86	0.80-0.93	3.0x10^−4	[21]
			T	0.89	0.80-0.98	0.02	[22]
		rs2588809	A	0.91	0.83-1.00	0.041	[17]
16q12	TOX3	rs3803662	A	1.09	1.01-1.17	0.022	[17]
			A	1.21	1.11-1.30	3.1x10^−6	[18]
			A	1.17	1.09-1.26	3.7x10^−5	[21]
19p13		rs8170	A	1.26	1.16-1.37	1.3x10^−7	[17]
			T	1.27	1.17-1.38	2.3x10^−8	[21]
			A	1.28	1.16-1.41	1.2x10^−6	[23]
			A	1.25	1.18-1.33	3.3x10^−13	[24]
		rs2363956	C	0.82	0.77-0.88	2.3x10^−8	[17]
			C	0.80	0.74-0.87	1.1x10^−7	[23]
		rs8100241	A	0.81	0.76-0.86	2.4x10^−13	[20]
			A	0.84	0.78-0.90	8.7x10^−7	[21]