Journal of Oncology / 2019 / Article / Tab 1 / Review Article
A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements Table 1 Odds ratios for TNBC for loci identified in more than one study.
Location Gene SNP Risk Allele OR/HR 95% CI P-value Reference 1q32 MDM4 rs4245739 C 1.18 1.13-1.23 4.3x10−15 [15 ] C 1.17 1.09-1.26 3.1x10−5 [16 ] C 1.19 1.11-1.29 4.0x10−6 [17 ] 2q35 rs13387042 G 0.93 0.87-1.00 0.049 [17 ] G 1.12 1.05-1.21 0.001 [18 ] 5p15 TERT rs10069690 A 1.28 1.23-1.33 2.4x10−33 [15 ] A 1.24 1.14-1.34 1.4x10−7 [17 ] A 1.25 1.16-1.34 1.1x10−9 [19 ] A 1.27 1.20-1.36 5.2x10−14 [20 ] rs2736108 T 0.77 0.69-0.87 8.3x10−6 [17 ] 6q25 ESR1 rs2046210 A 1.16 1.08-1.24 5.3x10−5 [17 ] A 1.23 1.16-1.31 5.5x10−12 [20 ] A 1.29 1.17-1.42 4.4x10−7 [21 ] rs3757318 A 1.33 1.17-1.51 9.3x10−6 [17 ] rs12662670 G 1.33 1.15-1.53 1.1x10−4 [21 ] 14q24 RAD51L1 rs999737 T 0.86 0.80-0.93 3.0x10−4 [21 ] T 0.89 0.80-0.98 0.02 [22 ] rs2588809 A 0.91 0.83-1.00 0.041 [17 ] 16q12 TOX3 rs3803662 A 1.09 1.01-1.17 0.022 [17 ] A 1.21 1.11-1.30 3.1x10−6 [18 ] A 1.17 1.09-1.26 3.7x10−5 [21 ] 19p13 rs8170 A 1.26 1.16-1.37 1.3x10−7 [17 ] T 1.27 1.17-1.38 2.3x10−8 [21 ] A 1.28 1.16-1.41 1.2x10−6 [23 ] A 1.25 1.18-1.33 3.3x10−13 [24 ] rs2363956 C 0.82 0.77-0.88 2.3x10−8 [17 ] C 0.80 0.74-0.87 1.1x10−7 [23 ] rs8100241 A 0.81 0.76-0.86 2.4x10−13 [20 ] A 0.84 0.78-0.90 8.7x10−7 [21 ]