Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches

Table 2

Summary of the number and proportion of IDH-wildtype and IDH-mutant glioblastoma patients with SNVs in genes in the RTK/Ras/PI(3)K, p53 DNA damage repair, WNT signalling, SHH, NOTCH, Rb, and G-protein pathways.

Pathway	IDH-wildtype				IDH-mutant
	Initial		Recurrent		Initial		Recurrent
	%	N	%	N	%	N	%	N
RTK/Ras/PI(3)K	79	30/38	43	3/7	66	2/3	0	0/1
p53 DNA damage repair	61	23/38	29	2/7	100	3/3	100	1/1
WNT signalling	58	22/38	57	4/7	33	1/3	100	1/1
SHH	16	6/38	0	0/7	0	0/3	0	0/1
NOTCH	8	3/38	0	0/7	0	0/3	0	0/1
Rb	5	2/38	0	0/7	0	0/3	0	0/1
G-protein	5	2/38	14	1/7	0	0/3	100	1/1