|
| First author | Study design | AJCC stage
Time (T) since diagnosis | Questionnaires | Sample size (response rate) | Main findings on HRQOL | Main findings on psychosocial outcome |
|
Beutel M. E. et al [36]
Fishbeck S. et al [43] | Cross-sectional Survey | Mainly stage I/II (41% staging was missing)
T since diagnosis:
6 - 9 yrs. (70%), ≥ 10 yrs. (30%) | EORTC QLQ-C30 [28]
Health Questionnaire Depression (PHQ-9) [51]
Multidimensional
General Anxiety disorder (GAD-7) [52]
Illness specific support Scale (ISSS) [53] | 1320 (52%) | Global HRQOL was comparable to general population
Lower emotional, cognitive and social functioning and higher symptom burden compared to general population. | Increased depression and anxiety compared to the general population.
36% was in need of psychosocial support.
Fear of recurrence of disease caused the highest burden. |
|
| Cromwell K.D. et al [45] | Prospective longitudinal study | Stage III
T since diagnosis:
0-30 mos. | FACT-M [31]
Lymphedema and Breast cancer questionnaire (LBCQ) [54] | 277 (71%) | Lymphedema impacts HRQOL. | Lower extremity lymphedema pts. cope less effectively but improve over time
Household chores and sleep are most impacted by lymphedema. |
|
| Palesh O. et al [37] | Cross-sectional survey | Stage unknown
Median T since diagnosis 77 mos, range(0-336) | Non validated electronically administered survey | 893 (18%) | _ | Melanoma survivors experience continuing anxiety long after treatment.
30% of the pts. reported emotional distress.
Long term survivors decreased use of skin protection and frequency of skin screening. |
|
Schubert-Fritze et al [38]
Schlesinger Raab A. et al [44] | Cross-sectional survey | Stage I/II
T since diagnosis: 2 yrs. | EORTC QLQ-C30 [28]
FACT-G [30, 55]
Mental Adjustment to Cancer Scale [56] | 1085 (61%) | Global HRQOL was comparable with the general population.
Number of co-morbidities, age and lymphadenectomy increased the risk for worse global HRQOL, role functioning and worry about the future. | Doctor patient communication was correlated with emotional and social functioning.
42% of the pts. worried about recurrence of disease. |
|
| Hamama-Raz Y et al [39, 40] | Cross-sectional survey | Stage I/II
T since diagnosis:
5 yrs. (36%)
≥ 5 yrs. (64%) | Mental Health Inventory (MHI) [57]
Cognitive Appraisal of Health Scale [58] | 400 (75%) | Mean well-being score and mean distress score are similar compared to general population | Subjective factors, such as appraisal of the threat, may be more predictive than medical factors in coping with cancer. Men and women cope differently. |
|
| Waldmann et al [41] | Cross-sectional survey | Stage I/II (59%)
Stage III (17%)
Stage IV (1.9%)
T since diagnosis:
Q1: 15 mos.
Q2: 39 mos. | EORTC QLQ-C30 [28] | 762 (59%) | No clinical meaningful differences on global HRQOL between Q1 and Q2. | _ |
|
| Holterhues C et al [42] | Cross sectional survey | Stage I/II (81%)
Stage III (8%)
Mean T since diagnosis:
4.6 (2.6) yrs. | Short Form Health Survey (SF-36) [59]
Impact of Cancer scale (IOC) [60] | 699 (80%) | Medical co-morbidity and female were the main predictors of impaired HRQOL. Impairment of HRQOL seems to be melanoma specific. | Time since diagnosis, tumor stage and co-morbidity were predictors of negative IOC scores.
85 pts. (35%) reported difficulties in obtaining life insurance, 98 (15%) obtaining mortgage. |
|
| Dieng M. et al [47] | Cross sectional survey | Stage 0/I/II
Mean T since diagnosis:
7.6 (6.5) yrs. | FACT-M [31]
Assessment of QOL-8 dimension scale (AQoL-8D) [61]
Fear of cancer recurrence Inventory (FCRI) [62] | 183 (89%) | High fear of recurrence was associated with a significant decrease of HRQOL.
AQoL8D is an alternative to the FACT-M, more sensitive to changes in psychological health and fear of recurrence and can be used to asses utility based health status. | _ |
|
| Loquai C. et al [63] | Cross-sectional survey | Stage 0/I/II (81%)
Stage III (13%)
Stage IV (5%)
T since diagnosis
0-2 yrs. (44%)
2-5 yrs. (26%)
≥ 5yrs. (31%) | Distress Thermometer (DT) with Problem List (PL) [64] | 734 (71%) | _ | 52 % reported ≥1 emotional problem
Presence of emotional problems, family problems and younger age were strongly associated with higher distress.
DT and Pl reliable identify distressed melanoma patients. |
|
