| | | Total (n=59) | GAP stage I (n=42) | GAP stage II/III (n=17) | p value |
| | Age, median (IQR) | 71.0 (66.0, 76.0) | 70.0 (64.8, 75.3) | 71.0 (66.5, 76.0) | 0.150 | | Male, No. (%) | 58 (98.3) | 41 (97.6) | 17 (100) | 0.521 | | BMI, median (IQR), kg/m2 | 23.2 (21.8, 25.6) | 23.2(21.7, 25.6) | 23.3(21.3, 25.9) | 0.426 | | Smoking exposure, No. (%) | | | | | | Never | 4 (6.8) | 2 (4.8) | 2 (11.8) | 0.084 | | Former | 34 (57.6) | 28 (66.7) | 6 (35.3) | | | Current | 21 (35.6) | 12 (28.6) | 9 (52.9) | | | Pack-years, median (IQR) | 40.0 (25.0, 50.0) | 40.0 (25.0, 50.0) | 41.0 (30.0, 50.0) | 0.542 | | Emphysema, No. (%) | 11 (18.6) | 7 (16.7) | 4 (23.5) | 0.540 | | ECOG score, No. (%) | | | | 0.003 | | 0, 1 | 38 (64.4) | 32 (76.2) | 6 (35.3) | | | 2, 3 | 21 (35.6) | 10 (23.8) | 11 (64.7) | | | FVC % pred, median (IQR) | 83.0 (68.0, 93.0) | 86.0 (80.0, 95.3) | 66.0 (61.5, 79.0) | <0.001 | | % pred, median (IQR) | 75.5 (65.0, 85.0) | 80.5 (68.5, 85.0) | 66.0 (54.3, 75.0) | 0.039 | | Location, No. (%) | | | | 0.856 | | Right upper lobe | 5 (8.5) | 3 (7.1) | 2 (11.8) | | | Right middle lobe | 11 (18.6) | 7 (16.7) | 4 (23.5) | | | Right lower lobe | 12 (20.3) | 8 (19.0) | 4 (23.5) | | | Left upper lobe | 17 (28.8) | 13 (31.0) | 4 (23.5) | | | Left lower lobe | 14 (23.7) | 11 (26.2) | 3 (17.6) | | | Abutting to fibrotic lesion, No. (%) | 43 (72.9) | 32 (76.2) | 11 (64.7) | 0.369 | | Peripheral, No. (%) | 45 (76.3) | 33 (78.6) | 12 (70.6) | 0.514 | | Stage, No. (%) | | | | 0.254 | | Limited stage | 32 (54.2) | 25 (59.5) | 7 (41.2) | | | Extensive stage | 27 (45.8) | 17 (40.5) | 10 (58.8) | | | Primary treatment, No. (%) | | | | 0.269 | | Conservative care | 6 (10.2) | 3 (7.1) | 3 (17.6) | | | Surgery | 6 (10.2) | 6 (14.3) | 0 (0.0) | | | Chemotherapy | 28 (47.5) | 19 (45.2) | 9 (52.9) | | | Concurrent chemoradiotherapy | 19 (32.2) | 14 (13.3) | 5 (29.4) | | | Median OS, median (IQR), months | 9.9 (5.3-21.5) | 16.1 (10.8-21.4) | 7.1 (3.2-11.1) | 0.002 | | Median PFS, median (IQR), months | 7.1 (3.6-18.6) | 8.4 (5.3-11.4) | 5.3 (3.4-7.1) | 0.036 |
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Abbreviations: BMI, body mass index; , carbon monoxide diffusing capacity; ECOG, Eastern Cooperative Oncology Group; FVC, forced vital capacity; GAP, gender, age, and physiology; IQR, interquartile range; OS, overall survival; PFS, progression-free survival. |
