Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

Table 1

The posttranslational modification sites of Snail for EMT.

Residues-modification	Kinase/Enzyme	Function	Cell Type	Reference
Phosphorylation
S11-p	PKA	TF activity	HEK 293T, MDCK	[19]
		Stabilization
	PKD1	Nuclear export of snail (Destabilization)	Breast epithelial cell	[20, 21]
		Suppression of EMT
S82-p	ERK2	Nuclear accumulation	Breast cancer	[22]
S92-p	CK2	TF activity	HEK 293T, MDCK	[19]
		Stabilization
S96/S100/	GSK3β	Degradation	prostate cancer	[23, 24]
S104/S107-p			Breast cancer
S104/S107-p	CK1	Degradation	prostate cancer	[24]
S104-p	ERK2	Nuclear accumulation	Breast cancer	[22]
T203-p	Lats2	Nuclear accumulation		[25]
		Stabilization
S246-p	PAK1	Nuclear accumulation	Breast cancer	[26, 27]
		TF activity	Non-small lung cancer
		Stabilization
	PI3K	Nuclear accumulation	Bladder cancer	[28]
Other posttranslational modifications
S112-gl	O-GlcNAc	Stabilization		[29]
K206/K234/	A20	Monoubiquitylation	Breast cancer	[30]
K235-ub		Stabilization